Psychiatry Mcqs 1

1. True or False Re: APs in schizophrenia
  1. The response to APs vary greatly between individuals
  2. There is no first choice AP for all
  3. SGAs are not superior to FGAs
  4. When non-clozapine SGAs are compared to each other Olanzapine is superior
  5. Risperidone is superior to other SGAs except olnz. and cloz.
2. When compared with FGAs the following SGAs have proven more efficacious
  1. Olanzapine
  2. Ziprazidone
  3. Aripiprazole
  4. Risperidone
  5. Amisulpride
3. True or false Re: APs in schizophrenia
  1. Depot preparations are associated with better global outcome and reduction in the frequency of hospital admission
  2. GASS and LUNSERS are questionnaires used to detect drug side effects in pts. on APs
  3. Following Depot administration it would take close 6-12 week reach a steady plasma concentration
  4. AP polypharmacy can cause sudden death
4. True of False Re: Neuroleptic equivalent doses
  1. Closely follows the drugs efficacy
  2. Related the maximum dose that can be prescribed
  3. Related to chlorpromazine equivalents
  4. Based on dopamine studies
  5. Only has value in FGAs
5. True of False Re: Maximum licensed doses
  1. Chlorpromazine – 1000 mg/day
  2. Haloperidol – 30 mg/day
  3. Clozapine 900mg/day
  4. Olanzapine 20mg/day
  5. Risperidone – 24mg/day

Answers                                 

1. True or False Re: APs in schizophrenia
  1. The response to APs vary greatly between individuals – T
  2. There is no first choice AP for all – T, due to above reason
  3. SGAs are not superior to FGAs – T, After reviewing the CATIE and CUTLES studies the world psychiatric association made this statement
  4. When non-clozapine SGAs are compared to each other Olanzapine is superior – T, Leucht et al 2009 Meta analysis, head-to-head comparison of SGAs
  5. Risperidone is superior to other SGAs except olnz. and cloz. – T, Leucht et al 2009 Meta analysis, head-to-head comparison of SGAs
2. When compared with FGAs the following SGAs have proven more efficacious
  1. Olanzapine – T
  2. Ziprazidone – F
  3. Aripiprazole – F
  4. Risperidone – T
  5. Amisulpride – T
3. True or false Re: APs in schizophrenia
  1. Depot preparations are associated with better global outcome and reduction in the frequency of hospital admission – T, Schooler (2003)
  2. GASS and LUNSERS are questionnaires used to detect drug side effects in pts. on APs – T, Glasgow Antipsychotic Side-Effect Scale (GASS) And the Liverpool University Neuroleptic Side-Effect Ratings Scale (LUNSERS), can be a useful first step in this process.
  3. Following Depot administration it would take close 6-12 week reach a steady plasma concentration – T
  4. AP polypharmacy can cause sudden death – T
4. True of False Re: Neuroleptic equivalent doses
  1. Closely follows the drugs efficacy – F, not related
  2. Related the maximum dose that can be prescribed – F, not related
  3. Related to chlorpromazine equivalents – T
  4. Based on dopamine studies – T, also clinical experience and guess work
  5. Only has value in FGAs – ?T, not useful for SGA
5. True of False Re: Re: maximum licensed doses
  1. Chlorpromazine – 1000 mg/day – T
  2. Haloperidol – 30 mg/day – T
  3. Clozapine 900mg/day – T
  4. Olanzapine 20mg/day – T
  5. Risperidone – 24mg/day – F, 16mg/day

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