Pharmacology Mnemonics 2

Insulin: mixing regular insulin and NPH “Not Ready,
Ready Now”:
Air into NPH
Air into Regular
Draw up Regular
Draw up NPH

 

 

Benzodiazepins: 3 members that undergo extrahepatic metabolism
Outside The Liver”:
Oxazepam
Temazepam
Lorazepam
These undergo extrahepatic metabolism and do not form active metabolites.

 

 

Guanethidine: mechanism GuaNEthidine prevents NE
(norepinephrine) release.

 

 

Parasympathetic vs. sympathetic neurotransmitters “No
sympathy for a Pair of Aces”:
Norepinephren is secreted in by the Sympathetic nervous system
while Acetylcholine is secreted in the Parasympathetic nervous
system.

 

 

Adrenoceptors: vasomotor function of alpha vs. beta ABCD:
Alpha = Constrict.
Beta = Dilate.

 

 

Beta 1 selective blockers “BEAM ONE up, Scotty”:
Beta 1 blockers:
Esmolol
Atenolol
Metropolol

 

 

Opiods: mu receptor effects “MD CARES“:
Miosis
Dependency
Constipation
Analgesics
Respiratory depression
Euphoria
Sedation

 

 

Cancer drugs: time of action between DNA->mRNA ABCDEF:
Alkylating agents
Bleomycin
Cisplastin
Dactinomycin/ Doxorubicin
Etoposide
Flutamide and other steroids or their antagonists (eg tamoxifen,
leuprolide)

 

 

Busulfan: features ABCDEF:
Alkylating agent
Bone marrow suppression s/e
CML indication
Dark skin (hyperpigmentation) s/e
Endrocrine insufficiency (adrenal) s/e
Fibrosis (pulmonary) s/e

 

 

Tricyclic antidepressants: members worth knowing “I have to
hide, the CIA is after me”:
Clomipramine
Imipramine
Amitrptyline
· If want the next 3 worth knowing, the DND is also after me:
Desipramine
Norrtriptyline
Doxepin

 

 

Asthma drugs: leukotriene inhibitor action zAfirlukast:
Antagonist of lipoxygenase
zIlueton: Inhibitor of LT receptor

 

 

Torsades de Pointes: drugs causing APACHE:
Amiodarone
Procainamide
Arsenium
Cisapride
Haloperidol
Eritromycin

 

 

Serotonin syndrome: components Causes HARM:
Hyperthermia
Autonomic instability (delirium)
Rigidity
Myoclonus

 

 

Beta blockers: B1 selective vs. B1-B2 non-selective A
through N: B1 selective
: Acebutalol, Atenolol, Esmolol, Metoprolol.
O through Z: B1, B2 non-selective:Pindolol, Propanalol, Timolol.

 

 

HMG-CoA reductase inhibitors (statins): side effects,
contraindications, interactions
 HMGCoA:
· Side effects:
Hepatotoxicity
Myositis [aka rhabdomyolysis]
· Contraindications:
Girl during pregnancy/ Growing children
· Interactions:
Coumarin/ Cyclosporine

 

 

Therapeutic index: formula TILE:
TI = LD50 / ED50

 

 

Antirheumatic agents (disease modifying): members CHAMP:
Cyclophosphamide
Hydroxycloroquine and choloroquinine
Auranofin and other gold compounds
Methotrexate
Penicillamine

 

 

Auranofin, aurothioglucose: category and indication Aurum
is latin for “gold” (gold’s chemical symbol is Au).
Generic Aur- drugs (Auranofin, Aurothioglucose) are gold
compounds.
· If didn’t learn yet that gold’s indication is rheumatoid arthritis, AUR- Acts
Upon Rheumatoid.

 

 

Antiarrhythmics: class III members BIAS:
Bretylium
Ibutilide
Amiodarone
Sotalol

 

 

MAOIs: indications MAOIS:
Melancholic [classic name for atypical depression]
Anxiety
Obesity disorders [anorexia, bulemia]
Imagined illnesses [hypochondria]
Social phobias
· Listed in decreasing order of importance.
· Note MAOI is inside MelAnchOlIc.

 

 

SIADH-inducing drugs ABCD:
Analgesics: opioids, NSAIDs
Barbiturates
Cyclophosphamide/ Chlorpromazine/ Carbamazepine
Diuretic (thiazide)

 

 

K+ increasing agents K-BANK:
K-sparing diuretic
Beta blocker
ACEI
NSAID
Ksupplement

 

 

Diuretics: thiazides: indications “CHIC to use
thiazides”:
CHF
Hypertension
Insipidous
Calcium calculi

 

 

Ribavirin: indications RIBAvirin:
RSV
Influenza B
Arenaviruses (Lassa, Bolivian, etc.)

 

 

Parkinsonism: drugs SALAD:
Selegiline
Anticholinenergics (trihexyphenidyl, benzhexol, ophenadrine)
L-Dopa + peripheral decarboxylase inhibitor (carbidopa, benserazide)
Amantadine
Dopamine postsynaptic receptor agonists (bromocriptine, lisuride,
pergolide)

 

 

Morphine: effects at mu receptor PEAR:
Physical dependence
Euphoria
Analgesia
Respiratory depression

 

 

Thrombolytic agents USA:
Urokinase
Streptokinase
Alteplase (tPA)

 

 

Anticholinergic side effects “Know the ABCD’S of
anticholinergic side effects”:
Anorexia
Blurry vision
Constipation/ Confusion
Dry Mouth
Sedation/ Stasis of urine

 

 

Teratogenic drugs “WTERATOgenic”:
Warfarin
Thalidomide
Epileptic drugs: phenytoin, valproate, carbamazepine
Retinoid
ACE inhibitor
Third element: lithium
OCP and other hormones (eg danazol)

 

 

Antiarrhythmics: classification I to IV MBA College
· In order of class I to IV:
Membrane stabilizers (class I)
Beta blockers
Action potential widening agents
Calcium channel blockers

 

 

Epilepsy types, drugs of choice “Military General
Attacked Weary Fighters Pronouncing ‘Veni
Vedi Veci’ After Crushing Enemies”:
· Epilepsy types:
Myoclonic
Grand mal
Atonic
West syndrome
Focal
Petit mal (absence)
· Respective drugsy:
Valproate
Valproate
Valproate
ACTH
Carbamazepine
Ethosuximide

 

 

Respiratory depression inducing drugs “STOP
breathing”:
Sedatives and hypnotics
Trimethoprim
Opiates
Polymyxins

 

 

Pulmonary infiltrations inducing drugs “Go BAN Me!”:
Gold
Bleomycin/ Busulphan/ BCNU
Amiodarone/ Acyclovir/ Azathioprine
Nitrofurantoin
Melphalan/ Methotrexate/ Methysergide

 

 

Migraine: prophylaxis drugs “Very Volatile 
P
harmacotherapeutic Agents For Migraine Prophylaxis”:
Verpamil
Valproic acid
Pizotifen
Amitriptyline
Flunarizine
Methysergide
Propranolol
· Bare bones version [eg Lippincott’s two], just Migraine Prophylaxis,
as above.

 

 

Benzodiazapines: ones not metabolized by the liver (safe to use in
liver failure)
 LOT:
Lorazepam
Oxazepam
Temazepam

 

 

Vigabatrin: mechanism Vi-GABATrIn:
ViGABA Transferase Inhibition

 

 

TB: antibiotics used STRIPE:
STreptomycin
Rifampicin
Isoniazid
Pyrizinamide
Ethambutol

 

 

Propythiouracil (PTU): mechanism It inhibits PTU:
Peroxidase/ Peripheral deiodination
Tyrosine iodination
Union (coupling)

 

 

Enoxaprin (prototype low molecular weight heparin): action,
monitoring
 EnoXaprin only acts on factor Xa.
Monitor Xaconcentration, rather than APTT.

 

 

Beta-blockers: nonselective beta-blockers “Tim Pinches
His Nasal Problem” (because he has a runny nose…):
Timolol
Pindolol
Hismolol
Naldolol
Propranolol

 

 

Nicotinic effects MTWTF (days of week):
Mydriasis/ Muscle cramps
Tachycardia
Weakness
Twitching
Hypertension/ Hyperglycemia
Fasiculation

 

 

Muscarinic effects SLUG BAM:
Salivation/ Secretions/ Sweating
Lacrimation
Urination
Gastrointestinal upset
Bradycardia/ Bronchoconstriction/ Bowel movement
Abdominal cramps/ Anorexia
Miosis

 

 

Phenytoin: adverse effects PHENYTOIN:
P-450 interactions
Hirsutism
Enlarged gums
Nystagmus
Yellow-browning of skin
Teratogenicity
Osteomalacia
Interference with B12 metabolism (hence anemia)
Neuropathies: vertigo, ataxia, headache

 

 

Gynaecomastia-causing drugs DISCOS:
Digoxin
Isoniazid
Spironolactone
Cimetidine
Oestrogens
Stilboestrol

 

Leave a Reply