Pharmacology MCQS 2

1q: A highly ionized drug
a. Is excreted mainly by the kidney
b. Can cross the placental barrier easily
c. Is well absorbed from the intestine
d. Accumulates in the cellular lipids

2q: All of the following hormones have cell surface receptors except
a. Adrenaline
b. GH
c. Insulin
d. Thyroxine

3q: Which one of the following is true of adrenal suppression due to steroid therapy?
a. It is not associated with atrophy of adrenal glands
b. It does not occur in patients receiving inhaled steroids
c. It should be expected in anyone receiving greater than 5mg of prednisolone daily
d. Following cessation, the stress response normalizes after 8 weeks

4q: With which of the following theophylline has an antagonistic interaction?
a. Histamine receptors
b. Bradykinin receptors
c. Adenosine receptors
d. Imidazoline receptors

5q: Which one of the following drugs increases gastrointestinal motility?
a. Glycopyrrolate
b. Atropine
c. Neostigmine
d. Fentanyl

6q: Which one of the following drugs has been shown to offer protection from gastric aspiration syndrome in a patient with symptoms of flux?
a. Ondansetron
b. Metaclopramide
c. Sodium citrate
d. Atropine

7q: The following drugss have significant drug interactions with digoxin except :
a. Cholestyramine
b. Thiazide diuretics
c. Quinine
d. Amlodipine

8q: One of the following is not true about nesiritide
a. It is a brain natriuretic peptide analogue
b. It is used in acutely decompensated heart failure
c. It has significant oral absorption
d. It has a short half life

9q: Dry mouth during antidepressant therapy is caused by blockade of
a. Muscarinic acetylcholine receptors
b. Serotonergic receptors
c. Dopaminergic receptors
d. GABA receptors

10q: The major difference between typical and atypical antipsychotics is that
a. The latter cause minimal or no increase in prolactin
b. The former cause tardive dyskinesia
c. The former are available as parenteral preparations
d. The latter cause substantial sedation

11q: Antipsychotic drug induced parkinsonism is treated by
a. Anticholinergics
b. Levodopa
c. Selegilline
d. Amantadine

12q: Oculogyric crisis is known to be produced by all of the following drugs except
a. Trifluoperazine
b. Atropine
c. Perchlorperazine
d. Perphenazine

13q: Inverse agonist of benzodiazepine receptor is
a. Phenobarbitone
b. Flumazenil
c. Beta-carboline
d. Gabapentin

14q: All of the following are hallucinogens except
a. LSD
b. Phencyclidine
c. Mescaline
d. Methylphenidate

15q: All of the following are topically used sulphonamides except
a. Sulphacetamide
b. Sulphadiazine
c. Silver sulphadiazine
d. Mafenide

16q: One of the following is not pencillinase susceptible
a. Amoxicillin
b. Pencillin G
c. Piperacillin
d. Cloxacillin

17q: The group of antibiotics which possess additional anti-inflammatory and immunomodulatory activities is
a. Tetracyclines
b. Polypeptide antibiotics
c. Fluoroquinolones
d. Macrolides

18q: Which one of the following is best associated with Lumefantrine?
a. Antimycobacterial
b. Antifungal
c. Antimalarial
d. Antiamoebic

19q: Which one of the following is used in therapy of Toxoplasmosis?
a. Artensunate
b. Thiacetazone
c. Ciprofloxacin
d. Pyrimethamine

20q: Nevirapine is a
a. Protease inhibitor
b. Nucleoside reverse transcriptase inhibitor
d. Fusion inhibitor

21q: Which one of the following drugs is “Topoisomerase I” inhibitor?
a. Doxorubicin
b. Irinotecan
c. Etoposide
d. Vincristine


22q: Etanercept acts by one of the following mechanisms
a. By blocking Tumor necrosis factor
b. By blocking bradykinin synthesis
c. By inhibiting COX-2
d. By blocking lipoxygenase


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